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Mitochondrial Dysfunction at the Crossroads of Necroptosis: Mechanisms, Molecular Mediators, and Therapeutic Opportunities 期刊论文

编号：

F871F1DFC0C8253B410B3951388518FF
作者：

Wang, Fengxin#^[1,2,3,4,5]Rui, Haiying^[1,2,3,4,5];Qin, Dandan(秦丹丹)^[1,2,3,4,5]Yu, Huaxiang^[1,2,3,4,5];Zou, Dan^[1,2,3,4,5];Zou, Wenyi^[1,2,3,4,5];Li, Yuting^[1,2,3,4,5];Li, Ran^[1,2,3,4,5];Chen, Yuguo(陈玉国)^[1,2,3,4,5]Xue, Li(薛丽)*^[1,2,3,4,5]
语种：

英文
期刊：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE ISSN：1582-1838 2026 年 30 卷 14 期 ; JUL 28
收录：
关键词：

cancer therapy cardiovascular disease inflammatory pathways mitochondrial dysfunction necroptosis neurodegeneration
摘要：

The conceptual landscape of cell death has evolved beyond the traditional dichotomy of apoptosis and necrosis to encompass diverse regulated pathways including necroptosis, autophagy, ferroptosis, and pyroptosis. Necroptosis, a caspase-independent inflammatory form of programmed cell death, has emerged as a critical driver of the pathogenesis of cardiovascular disorders, neurodegenerative diseases, and cancer. Concurrently, our understanding of mitochondrial biology has undergone a paradigm shift: mitochondria are no longer viewed merely as bioenergetic powerhouses, but as dynamic signalling hubs that orchestrate metabolic reprogramming, cellular homeostasis, and ultimate cell fate decisions. In this regard, a growing body of evidence suggests that mitochondrial dysfunction is a central rheostat that enables necroptotic execution. This review delineates the mechanistic interplay between necroptosis and mitochondrial dysfunction and systematically analyzes the key molecular mediators and pathological pathways through which mitochondrial dysregulation drives necroptotic activation. Furthermore, this review identifies actionable therapeutic targets and translational strategies for modulating necroptosis in related diseases.
推荐引用方式
GB/T 7714：

Wang Fengxin,Rui Haiying,Qin Dandan, et al. Mitochondrial Dysfunction at the Crossroads of Necroptosis: Mechanisms, Molecular Mediators, and Therapeutic Opportunities [J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2026,30(14).
APA：

Wang Fengxin,Rui Haiying,Qin Dandan,Yu Huaxiang,&Xue Li.(2026).Mitochondrial Dysfunction at the Crossroads of Necroptosis: Mechanisms, Molecular Mediators, and Therapeutic Opportunities .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,30(14).
MLA：

Wang Fengxin, et al. "Mitochondrial Dysfunction at the Crossroads of Necroptosis: Mechanisms, Molecular Mediators, and Therapeutic Opportunities" .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 30,14(2026).
入库时间：

8/11/2026 10:08:36 PM
更新时间：

8/12/2026 12:04:29 AM

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