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Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration 期刊论文

编号：

871A6D2B462DD9985CCB77003DA53C6F
作者：

Zhao, Dawang(赵达旺)#^[1,2]Zhang, Jing#^[1,2]Chen, Chen#^[1,2]Sun, Weiyi^[1,2];Liu, Ying^[1,2];Han, Maosen^[1,2];Zhang, Yulin(张玉霖)^[2,3,4]Fu, Zhipeng^[1,2];Shi, Chongdeng^[1,2];Zhao, Xiaotian^[1,2];Yang, Zhenmei^[1,2];Tang, Chunwei^[1,2];Zhao, Kun^[1,2]Zhu, Danqing^[5];Zhang, Yuankai(张元凯)*^[1,2]Cheng, Lei(程雷)*^[1,2]Jiang, Xinyi(姜新义)*^[1,2]
语种：

英文
期刊：

ADVANCED MATERIALS ISSN：0935-9648 2025 年 37 卷 7 期 ; FEB
收录：
关键词：

alpha-Klotho aging cell reinvigoration circRNA intervertebral disc degeneration nucleus pulposus progenitor cells
摘要：

The decreased regeneration potential of aging nucleus pulposus resident progenitor cells (NPPCs) fails to resist intervertebral disc degeneration (IVDD), and strategies to remodel the regeneration capacity of senescent NPPC are urgently needed. A decrease in Klotho gene expression in NPPCs of both old mice and humans exacerbates the impaired regenerative functionality of NPPC. Here, an NPPC-targeted lipid thymine nanoparticle (NT-LNP) is reported for the in situ manipulation of the regenerative repair potential of NPPCs, restoration of degenerated nucleus pulposus tissue, and mitigation of IVDD. Specifically, the results showed that the in-house customized lipid nanoparticles efficiently introduced Klotho circular ribonucleic acid (circRNA) into NPPCs to engender a renascent phenotype and tuned the balance of extracellular matrix synthesis/catabolism in vitro and in vivo. Moreover, an intradiscal injectable hydrogel system that scavenges chemokines (MCP1 and IL8) in tandem with NPPCs rejuvenated NT-LNPs in the IVD, modulating the inflammatory environment and synergistically promoting the regeneration of degenerated intervertebral discs. In summary, the findings establish that NPPCs can be re-engineered to be youthful and pluripotent to maintain homeostasis and rejuvenation, thereby providing a reversible treatment strategy for IVDD with broad application in other senescence-related diseases.
推荐引用方式
GB/T 7714：

Zhao Da-wang,Zhang Jing,Chen Chen, et al. Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration [J].ADVANCED MATERIALS,2025,37(7).
APA：

Zhao Da-wang,Zhang Jing,Chen Chen,Sun Weiyi,&Jiang Xinyi.(2025).Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration .ADVANCED MATERIALS,37(7).
MLA：

Zhao Da-wang, et al. "Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration" .ADVANCED MATERIALS 37,7(2025).
入库时间：

1/7/2025 9:34:40 PM
更新时间：

3/20/2025 9:32:57 PM
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