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Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension 期刊论文

编号：

6D6D29A30D4C25767FD252A96B367314
作者：

Yan, Xuefang(闫雪芳)#^[1,2]Jin, Jiajia^[1,2]Su, Xinhuan^[3,4];Yin, Xianlun(殷宪伦)^[1,2]Gao, Jing^[1,2];Wang, Xiaowei(王晓微)^[1,2]Zhang, Shucui(张书翠)^[1,2]Bu, Peili(卜培莉)^[1,2]Wang, Mansen^[5];Zhang, Yun(张运)^[1,2]Wang, Zhe(王哲)*^[3,4]Zhang, Qunye(张群业)*^[1,2]
语种：

英文
期刊：

CIRCULATION RESEARCH ISSN：0009-7330 2020 年 126 卷 7 期 (839 - 853) ; MAR 27
收录：
关键词：

arachidonic acid bacteroides corticosterone hypertension microbiota
摘要：

Rationale:
High-salt diet is one of the most important risk factors for hypertension. Intestinal flora has been reported to be associated with high salt-induced hypertension (hSIH). However, the detailed roles of intestinal flora in hSIH pathogenesis have not yet been fully elucidated.
Objective:
To reveal the roles and mechanisms of intestinal flora in hSIH development.
Methods and Results:
The abovementioned issues were investigated using various techniques including 16S rRNA gene sequencing, untargeted metabolomics, selective bacterial culture, and fecal microbiota transplantation. We found that high-salt diet induced hypertension in Wistar rats. The fecal microbiota of healthy rats could dramatically lower blood pressure (BP) of hypertensive rats, whereas the fecal microbiota of hSIH rats had opposite effects. The composition, metabolism, and interrelationship of intestinal flora in hSIH rats were considerably reshaped, including the increased corticosterone level and reduced Bacteroides and arachidonic acid levels, which tightly correlated with BP. The serum corticosterone level was also significantly increased in rats with hSIH. Furthermore, the above abnormalities were confirmed in patients with hypertension. The intestinal Bacteroides fragilis could inhibit the production of intestinal-derived corticosterone induced by high-salt diet through its metabolite arachidonic acid.
Conclusions:
hSIH could be transferred by fecal microbiota transplantation, indicating the pivotal roles of intestinal flora in hSIH development. High-salt diet reduced the levels of B fragilis and arachidonic acid in the intestine, which increased intestinal-derived corticosterone production and corticosterone levels in serum and intestine, thereby promoting BP elevation. This study revealed a novel mechanism different from inflammation/immunity by which intestinal flora regulated BP, namely intestinal flora could modulate BP by affecting steroid hormone levels. These findings enriched the understanding of the function of intestinal flora and its effects on hypertension.
推荐引用方式
GB/T 7714：

Yan Xuefang,Jin Jiajia,Su Xinhuan, et al. Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension [J].CIRCULATION RESEARCH,2020,126(7):839-853.
APA：

Yan Xuefang,Jin Jiajia,Su Xinhuan,Yin Xianlun,&Zhang Qunye.(2020).Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension .CIRCULATION RESEARCH,126(7):839-853.
MLA：

Yan Xuefang, et al. "Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension" .CIRCULATION RESEARCH 126,7(2020):839-853.
入库时间：

2/5/2021 1:03:42 AM
更新时间：

2/5/2021 1:03:42 AM
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