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Circular RNA hsa-circ-000881 suppresses the progression of lung adenocarcinoma in vitro via a miR-665/PRICKLE2 axis 期刊论文

编号：

5F310562BAFA2442E75BFF00EF72BB9E
作者：

Huang, Chu(黄楚)#^[1]Yue, Weiming(岳韦名)^[1]Li, Lin(李林)^[1]Li, Shuhai(李树海)^[1]Gao, Cun(高存)^[1]Si, Libo(司立博)^[1]Qi, Lei(亓磊)^[1]Cheng, Chuanle(程传乐)^[1]Lu, Ming(鲁铭)^[1]Chen, Guanqing(陈观卿)^[1]Cui, Jingjing(崔京京)^[1]Zhao, Renchang(赵仁昌)^[1]Li, Yongmeng^[1];Tian, Hui(田辉)*^[1]
语种：

英文
期刊：

ANNALS OF TRANSLATIONAL MEDICINE ISSN：2305-5839 2021 年 9 卷 6 期 ; MAR
收录：
关键词：

Circ-000881 miR-665 lung adenocarcinoma (LUAD) PRICKLE2 tianhuiql@126 com
摘要：

Background: Circular RNA (circRNA) has become a new focus in the field of tumor biology research in recent years. Many circRNAs have been showed to play an important role in the progression of lung adenocarcinoma (LUAD). In this work, we studied the oncological role of hsa-circ-000881 in LUAD and attempted to explore the related mechanism.
Methods: The relative expressions of hsa-circ-000881, miR-665, and PRICKLE2 were detected by RTqPCR or western blot. Functional assays were conducted to analyze the role of hsa-circ-000881 in the proliferation, migration, and invasion of LUAD cells. A luciferase reporter assay was performed to verify whether hsa-circ-000881, miR-665, and PRICKLE2 interact with each other.
Results: Circ-000881 was remarkably downregulated in LUAD. Overexpression of circ-000881 attenuated cell growth, migration, and invasion, whereas its knockdown enhanced the malignancy of LUAD cells. The results of luciferase reporter assay and bioinformatics analysis confirmed that circ-000881 served as a sponge for miR-665, and PRICKLE2 was a direct target of miR-665.Overexpression of miR-665 or silencing of PRICKLE2 abolished circ-000881-mediated inhibition of malignant tumor behavior in LUAD cells.
Conclusions: Circ-000881 has inhibitory effects on LUAD via a miR-665/PRICKLE2 axis, suggesting that circ-000881 may be an underlying therapeutic target for LUAD.
推荐引用方式
GB/T 7714：

Huang Chu,Yue Weiming,Li Lin, et al. Circular RNA hsa-circ-000881 suppresses the progression of lung adenocarcinoma in vitro via a miR-665/PRICKLE2 axis [J].ANNALS OF TRANSLATIONAL MEDICINE,2021,9(6).
APA：

Huang Chu,Yue Weiming,Li Lin,Li Shuhai,&Tian Hui.(2021).Circular RNA hsa-circ-000881 suppresses the progression of lung adenocarcinoma in vitro via a miR-665/PRICKLE2 axis .ANNALS OF TRANSLATIONAL MEDICINE,9(6).
MLA：

Huang Chu, et al. "Circular RNA hsa-circ-000881 suppresses the progression of lung adenocarcinoma in vitro via a miR-665/PRICKLE2 axis" .ANNALS OF TRANSLATIONAL MEDICINE 9,6(2021).
入库时间：

5/16/2021 10:23:33 PM
更新时间：

5/16/2021 10:23:33 PM
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