首页 / 院系成果 / 成果详情页

RNA polymerase I inhibitor CX-5461 suppresses cervical cancer cell growth by inducing DNA damage and mitotic catastrophe and enhances cisplatin sensitivity 期刊论文

编号：

4A7720DD4E87A3E52ECEF4A74EE220CC
作者：

Liu, Xiaoli(刘晓丽)#^[1,2]Xu, Ting^[1];Wu, Jiaqi^[1];Zhou, Baokun^[1,2];Wen, Jinghao^[1];Zhang, Youzhong(张友忠)^[1]Cui, Baoxia(崔保霞)^[1]Chiang, ChengMing^[3,4,5];Wang, Jianli(王建丽)*^[1]
语种：

英文
期刊：

BIOCHEMICAL PHARMACOLOGY ISSN：0006-2952 2026 年 248 卷 ; JUN
收录：
关键词：

Cervical cancer CX-5461 DNA damage Mitotic catastrophe Cell death Cisplatin
摘要：

Cervical cancer is one of the most common malignant tumors among women worldwide. In some regions, its incidence and mortality rates remain high, and patients with HPV-unassociated tumors often have a poor prognosis. Those with advanced or recurrent disease frequently show unsatisfactory treatment outcomes due to metastasis and chemoresistance. Ribosome biogenesis is notably active in various cancer cells and has emerged as a potential therapeutic target. CX-5461, a specific inhibitor of RNA polymerase I, was investigated in this study for its therapeutic effect and underlying mechanism in cervical cancer. The results demonstrated that CX-5461 significantly inhibits the proliferation of cervical cancer cells, activates the ATM/ATR pathway, and induces DNA damage. Furthermore, it leads to abnormal accumulation of Cyclin B1 and aberrant activation of phospho-CDK1-T161, driving cells with DNA damage into mitosis. This process ultimately triggers mitotic catastrophe, resulting in cell death or senescence. When combined with cisplatin, CX-5461 enhances the sensitivity of cervical cancer cells to this chemotherapeutic agent. In conclusion, CX-5461 demonstrates potential therapeutic value for cervical cancer, particularly as a new strategy for patients with primary or platinum-resistant disease.
推荐引用方式
GB/T 7714：

Liu Xiaoli,Xu Ting,Wu Jiaqi, et al. RNA polymerase I inhibitor CX-5461 suppresses cervical cancer cell growth by inducing DNA damage and mitotic catastrophe and enhances cisplatin sensitivity [J].BIOCHEMICAL PHARMACOLOGY,2026,248.
APA：

Liu Xiaoli,Xu Ting,Wu Jiaqi,Zhou Baokun,&Wang Jianli.(2026).RNA polymerase I inhibitor CX-5461 suppresses cervical cancer cell growth by inducing DNA damage and mitotic catastrophe and enhances cisplatin sensitivity .BIOCHEMICAL PHARMACOLOGY,248.
MLA：

Liu Xiaoli, et al. "RNA polymerase I inhibitor CX-5461 suppresses cervical cancer cell growth by inducing DNA damage and mitotic catastrophe and enhances cisplatin sensitivity" .BIOCHEMICAL PHARMACOLOGY 248(2026).
入库时间：

3/18/2026 10:06:02 PM
更新时间：

3/18/2026 10:06:02 PM

浏览次数：18  下载次数：0

分享到：

浏览次数：18

下载次数：0

打印次数：0