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LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression 期刊论文

编号：

0C22D4C8963FF48C8675B145A747CE20
作者：

Liu, HaiTing(刘海亭)#^[1,2,3]Gao, ZhaoXin^[1,2,3];Li, Feng(李峰)^[4]Guo, XiangYu(郭翔宇)^[1,2,3]Li, ChunLan^[1,2,3];Zhang, Han^[1,2,3];Zhao, RuiNan^[1,2,3];Liu, Yuan(刘媛)^[5]Shi, DuanBo(石端博)^[1,2,3]Zhu, WenJie*^[1,2,3]Gao, Peng*^[1,2,3]
语种：

英文
期刊：

CELL DEATH AND DIFFERENTIATION ISSN：1350-9047 2024 年 31 卷 2 期 (188 - 202) ; FEB
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摘要：

Abnormal long noncoding RNA (lncRNA) expression plays an important role in tumor invasion and metastasis. Here, we show that lncRNA LY6E divergent transcript (LY6E-DT) levels are increased in breast cancer (BC) tissues. Transcription factor SP3 binds directly to the LY6E-DT promoter, activating its transcription. Moreover, LY6E-DT N6-methyladenosine modification by methyltransferase-like protein 14 (METTL14) promotes its expression, dependent on the "reader" insulin-like growth factor 2 mRNA binding protein 1(IGF2BP1)-dependent pathway. Notably, we discovered that the lncRNA LY6E-DT encodes a conserved 153-aa protein, "Metastatic-Related Protein" (MRP). Both LY6E-DT and MRP promote BC invasion and metastasis, and MRP expression could distinguish BC patients with lymph node metastasis from those without. Mechanistically, MRP binds heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC), enhancing the interaction between HNRNPC and epidermal growth factor receptor (EGFR) mRNA, increasing EGFR mRNA stability and protein expression and subsequently activating the phosphatidylinositol 3-kinase/protein kinase B signaling (PI3K) pathway. LncRNA LY6E-DT promotes the interaction between Y box binding protein 1 (YBX1) and importin alpha 1 and increases YBX1 protein entry into the nucleus, where it transcriptionally activates zinc finger E-box-binding homeobox 1(ZEB1). Our findings uncover a novel regulatory mechanism underlying BC invasion orchestrated by LY6E-DT and its encoded MRP.
推荐引用方式
GB/T 7714：

Liu Hai-Ting,Gao Zhao-Xin,Li Feng, et al. LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression [J].CELL DEATH AND DIFFERENTIATION,2024,31(2):188-202.
APA：

Liu Hai-Ting,Gao Zhao-Xin,Li Feng,Guo Xiang-Yu,&Gao Peng.(2024).LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression .CELL DEATH AND DIFFERENTIATION,31(2):188-202.
MLA：

Liu Hai-Ting, et al. "LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression" .CELL DEATH AND DIFFERENTIATION 31,2(2024):188-202.
入库时间：

1/4/2024 9:50:03 AM
更新时间：

1/4/2024 9:50:03 AM
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